Send Free Mobile Text Messages to Your Friends and Family ...
Many scientific studies over a time frame have proved how the people with common sense of humor may have greater and healthier duration of life. In our planet where time means everything you normally do not have the time to check the various fun books or pocket joke books. You can read the varied jokes or fun related topics your run and can even read them on in the future or time. When reading these fun related messages necessarily make it a habit to save lots of your favorite ones in a very Notepad or maybe a Word - Pad file. If you possibly can remember them then it might be great as you possibly can share this your friend circle. Person with a very good humor may be known as to the lifeline of a very good social circle.
Free SMS websites are available in plenty, hence there wouldn't be any symptom in locating site website for. Thus, enjoy another benediction of Internet which has given us an easy way of messaging through it. Stay connected. Sending Free SMS Text Messages the actual Internet to Mobile Phones - Text Messages are fast becoming the preferred means of short message communication. Often far cheaper than the comparable cellphone call on most cellphone networks the SMS service offers an easy and fast substitute for making a phone call. Depending on what Mobile Phone (or cell phone) network you utilize, the fee of sending a SMS Text Message can differ from being included free within your monthly contract, to a few cents per message.
You will be able to earn a gentle stream of greenbacks once they stay subscribed to the service. Are you will still using the traditional mobile phones as a medium to send out your SMS Well, enough time is changing therefore is the popularity. Now far more lucrative method of sending SMS through Internet comes as method that has changed the best way people communicate. Free SMS is the best way that comes forth as a medium whereby you may send will SMS through different cellphones. So don't feel disgusted or handicapped when you your mobile phone isn't working because you will still are able to send your SMS. Free SMS are helpful if you find yourself working the actual World Wide Web and suddenly you stumble upon many new websites or shops, which you wish to, send to your mates, you can do so directly using the help within your free SMS websites that allow you to send free SMS over the country to your mobile number.
Unless of course your product is only for the kids, jargon could be quite a turnoff for your older get older. Simply utilize standard phrases and vocabulary the actual regular individual is accustomed to. A few modern phrases might not hurt nevertheless use caution your terminology probably deter many people or be product drawing clients to your company. Picture yourself owning a text messaging club with thousands of participants as a couple of companies have. You will need a supplier which can enable this type of mass communications at cost you really feel confident with. Consider attracting new customers to your shop by utilizing texts discover how to include text messages your current internet site to be an online wonder.
Foreclosure listings santa monica | Boomerding Real Estate Blog
FORECLOSURE LISTINGS SANTA MONICA
?
We should first establish what Santa Monica Foreclosure means. Foreclosure goes under many names;
REO, Real Estate Owned Properties, Lender Owned, Owned by Bank and I could list many more but these are the most popular. The term foreclosure is really not correct when you see a listing that says ?Foreclosures Santa Monica ? Foreclosure is a verb showing an action has being taken not how the listing is being sold. The property should be sold ?REO Santa Monica Houses? or Lender Owned Real Estate ?Santa Monica Houses?
?
For the sake not to confuse people I will use the term Foreclosure throughout this article.
?
There has been a lot of talk about the deals you can get today with properties that have been foreclosed and are for sale as an REO.
Buying a Santa Monica Foreclosure has many pros and cons
1. Pros
a. You can sometimes a find a below market price on listings
b. There are many houses on the market due to economic conditions.
c. Banks take into account and lower the prices knowing work needs to be done
d. Banks are usually eager to sell these properties and usually act fast.
e. For cash buyers the bank usually takes an additional discount
2. Cons
a. The property is usually not in the best of conditions. Remember that the former owner did not have the money to pay the mortgage let along keep the property up
b. The bank will sell the property as is and unless there are major health hazards have no obligation to fix anything. What you see is what you get
c. You are dealing with a bank so there are no emotions involved and when they take a position on any part of the transaction they are usually inflexible.
d. Banks have had the house appraised numerous times and are very up to date with market conditions don?t expect to buy a Santa Monica Foreclosure at a fire sale price
e. Special transactional steps and paperwork
3. Conclusion
a. When looking for, Foreclosure listings Santa Monica, you can find great deals but there are a lot that are also not discounted enough to balance the negative aspects
?
Now the question is where you look for Santa Monica foreclosures:
1. The easiest is looking through the newspapers
2. Talking to a Santa Monica Realtor that specializes in Bank Owned Properties
3. Of course there are many publications on line that specialize in ?Foreclosure News Santa Monica?
4. To get a total reference guide to bank foreclosures and to see Foreclosure Listings ? Santa Monica, here is a link to my website that specializes in foreclosures Santa Monica Foreclosure. West LA Real Estate Group
?
As in all communities, Foreclosures Santa Monica , are not located in all areas. The upscale areas of North of Montana, Santa Monica Mountains, and beach houses have not been economically hit that hard and this there are not that many Bank Owned Properties. You will find Foreclosure Listings Santa Monica in the blue collar area near Venice, Sunset and Ocean Park. These neighborhoods have a lot of Santa Monica Foreclosures.
Sales Management Program Combines Creativity And Business ...
Product sales Administration Software Combines Creativeness And Enterprise Abilities
Write-up by Emma
Outstanding interpersonal expertise, outstanding listening and oral communication skills, self-directed, flourish underneath pressure, very arranged: If these phrases explain you, the Graduate Certificate system in Marketing ? Sales and Account Management might be your route to job results. This revenue management software takes just two semesters to full and focuses on guaranteeing that college students obtain a strong foundation in the intricacies of obtaining and keeping associations with key client accounts.
Performed out of Progress Campus ? which is Centennial College?s greatest campus, centrally situated and houses a lot of of the institutions company packages ? this undertaking provides enough option for networking. In addition, pupils can communicate to their professors about sector possibilities as these professionals occur from the product sales management area with extensive knowledge in revenue, negotiation and account management in the organization-to-business realm.
An perfect harmony in between principle and hands-on learning is supplied so that pupils are equipped with a broad selection of skills on graduation that will make them instantaneously employable. The endeavor extensively employs learner-centered techniques these kinds of as: part-taking part in, simulation and circumstances, with a concentrate on establishing selling, negotiating and presentation abilities. Arms-on education is also presented in using product sales force automation software package. Certain programs inside the sales administration program include: Circumstance Analysis and Advertising and marketing Metrics, Fundamentals of Selling, Fundamentals of Challenge Administration, B2B Marketing, Strategic Account Improvement, Revenue and Account Management and other people.
In purchase to graduate from the revenue administration software, students need to preserve a C level average and an overall GPA of 2.. Once they receive their Ontario Higher education Graduate Certificate, graduates of the sales management plan stroll absent with ample knowledge to use for a number of work. If, however, students would like to obtain even a lot more encounter, an optional third semester internship in the revenue account management program is available.
People fascinated in implementing to this profits administration program need to submit an official transcript demonstrating proof of productive completion of a publish-secondary sophisticated diploma or degree plan. They may possibly also be necessary to carry out an job interview with officials, submit a resume and endure an English and/or math abilities assessment. Centennial School will also contemplate candidates presenting a blend of partial article-secondary education and pertinent work experience, open up to all disciplines.
On product sales management software graduation, college students go onto have careers are: crucial account professionals, account executives, business product sales reps, profits professionals, technical sales associates, revenue consultants, revenue coordinators, within revenue representatives, territory profits representatives and a lot more. Regardless of the diverse positions, essentially, the discipline of Marketing: Revenue and Account Management entails getting and sustaining relationships with key shopper accounts of mid to big sized firms that have their very own revenue power. These firms range from ones who handle healthcare and dental technologies to these providing software program and pharmaceutical merchandise.
About the Creator
Emma authored this report about Centennial College?s Sales Account Management Plan undertaking, which consists of courses such as B2B Marketing and advertising, Strategic Account Growth and a lot more.
We have discovered some important enablers that will make your strategic account management program a lot more effective. Below, SAMA President and CEO Bernard Quancard talks about Engaging the C-Amount.
A fried-chicken-eating contest and more food and drink events this ...
Thursday22
The documentary Capones Whiskey: The Story of Templeton Rye premieres tonight at Mayne Stage Theater, followed by a QA with director Kristian Day and Gapers Block publisher Andrew Huff, plus a Templeton Rye cocktail reception. 8 PM, Mayne Stage Theater, 1328 W. Morse, 773-381-4554, $10-15.
More food and drink events after the jump.
The Southern holds a fried-chicken-eating contest with a $200 prize. E-mail to sign up. 8 PM, the Southern, 1840 W. North, 773-342-1840, $20 to enter, free to watch.
Wicker Parks Francescas Forno hosts Let Them Drink Bourbon, a five-course dinner paired with small-batch bourbon. Fred Noe, great-grandson of Jim Beam, will speak about the featured bourbons and the history of small-batch bourbon. Dishes include brown-sugar-glazed bacon jerky paired with Moonshine, and pancetta-wrapped striped bass paired with Basil Haydens bourbon. Reservations required. 8-10 PM, Francescas Forno, 1576 N. Milwaukee, 773-770-0184, $45.
Weegees Lounge hosts a bottomless Three Floyds pint night, with all proceeds going to the Saint Baldricks Foundation to fight childhood cancer. A $20 donation provides unlimited Three Floyds drafts, including: Zombie Dust, Gumballhead, Ham on Rye and Topless Witch. A 22-ounce sample of the rare, once-a-year Dark Lord brew will be auctioned off 8 PM, Weegees Lounge, 3659 W. Armitage, 773-384-0707, $20.
Friday23
Pskbord, the traditional Swedish Easter feast that marks the end of Lent, will be celebrated at Ikea today with an all-you-can-eat smorgasbord. Dishes include smoked salmon, Swedish ham, meatballs, herring, and assorted Swedish desserts. Tickets must be purchased in person. 5-8 PM, Ikea Schaumburg and Ikea Bolingbrook, 1800 E. McConnor Parkway, Schaumburg, 750 E. Boughton Road, Bolingbrook, 847-969-9700 and 630-972-7900, $9.99, $2.49 for kids under 12.
UNICEFs second annual Taste of Tap event is tonight, a fund-raiser for World Water Week in which thousands of restaurants nationwide help provide clean drinking water in Vietnam, Togo, Mauritania, and Cameroon (among others), by asking diners to donate a dollar for their drinking water. Former Top Chef contestant Dale Levitski of Sprout as well as chefs from Crux, Centered Chef, and A Razor, A Shiny Knife will take part in live cooking demonstrations and serve water-themed food and drink. Theres also a silent auction. Purchase tickets here. For more information or to register as a volunteer with Tap Project click here. 7-10 PM, Centered Chef, 177 N. Ada, 312-226-2433, $50.
Saturday24
Sergeant David J. Haynes and Christopher Garlington, authors of The Beat Cops Guide to Chicago Eats, talk about what cops eat and purported hassles involved. Hosted by Chicago Foodways Roundtable. 10 AM, Kendall College School of Culinary Arts room 632, 900 N. Branch, 847-432-8255, $3.
Bread and Wine and Vinejoy host a house-made charcuterie and sustainable wine dinner. The five-course menu includes chicken liver pat paired with Tatomer 09 Riesling and pig face pancetta paired with Shakedown White, a blend of sauvignon blanc, muscat, and viognier. A coupon for 10 percent off retail items is included. Seating is limited. 2-4 PM, Bread and Wine, 3732 W. Irving Park, 773-866-5266, $25.
Standard Market, a new 33,000-square-foot specialty food store, is holding an open house today. It includes a chili cook-off, wine tastings, meet the farmer sessions, more than 20 vendor samples, face painting, musician Cary Kanno, stilt walking, balloon artists, prizes every hour, and a live game show. 11 AM-8 PM, Standard Market, 333 E. Ogden, Westmont, 630-366-7030, free.
Its Sausagefest 2012 at Haymarket Pub and Brewery. Theyre pairing 15 varieties of their handmade sausages with 30 different cheeses and 30 microbrews. Tickets on sale here. 1-5 PM, Haymarket Pub and Brewery, 737 W. Randolph, 312-638-0700, $45.
Monday26
FearNoArt presents The Dinner Party, a conversation over dinner between three artists and a chef streamed live on Ihe internet. Tonights installment features blues musician Billy Branch, Poetry Slam founder Marc Smith, MCA curator Naomi Beckwith and Three Aces chef Matt Troost. The opening act is performance painter Stacy Bowie and violinist Edith Yokley. Dinner sampling included, no late seating. Or watch free online at 7:30 PM. 7 PM show, 8:30 dinner, Mayne Stage, 1328 W. Morse, 866-468-3401, $25.
Tuesday27
Whats Brewing in Chicago? The Politics of Beer is a discussion of the history and politics of Chicagos pubs and breweries. The speakers will be Elizabeth Garibay, public program manager of the Chicago History Museum and founder of the Tales, Taverns Towns web project, and Pete Crowley, president of the Illinois Craft Brewers Guild and owner of the Haymarket Pub and Brewery. Registration required. 6:30-8 PM, Haymarket Pub and Brewery, 737 W. Randolph, 312-422-5580, free.
The Stew Supper Clubs A Survivalist Supper is a prix-fixe dinner featuring potential foods of the apocalypse. Cocktails included; vegetarian options available with prior notice. Click here for tickets. 7 PM, Darkroom, 2210 W. Chicago, 773-216-5580, $45.
Wednesday28
It might feel like summer outside, but winter vegetables are still in season. Sepia hosts a locally sourced five-course winter-themed dinnersay, duck-fat fried chicken with sweet potatoes, mustard greens, and miso paired with a 2010 Fessina Laeneopartially to benefit Green City Market and in conjunction with the nonprofit Growing Power. It includes welcome cocktails and wine pairings. 6:30 PM, Sepia, 135 N. Jefferson, 312-441-1920, $115.
Desserts for Deserts, sponsored by Fed Up, features sweets from Hoosier Mama Pie Company, Katherine Anne Confections, and Uncommon Ground, among others. All proceeds go to the nonprofit Fresh Moves in the effort to provide needy Chicago neighborhoods with healthy food options. Ticket sales are here. 7 PM VIP reception, 8-10 PM, Greenhouse Loft, 2545 W. Diversey, 773-569-0035, $55-75.
A tasting of Alpine Spring, a new unfiltered German-style beer from Samuel Adams, is hosted by brand rep Zach Pine. The beer is described as crisp and slightly sweet with bright citrus and spicy hop notes. There will be a raffle for a Samuel Adams tasting kit as well. 5-7 PM, Franklin Tap, 325 S. Franklin, 312-212-3262, free.
Podcast Basics For Frenchtown MLM Business Bloggers | Stockton ...
Today?s Frenchtown direct selling article is for Frenchtown internet rookies who want to kick up their web marketing a notch by adding a podcast to their Frenchtown home business blog.
A podcast is a multimedia file that is downloaded for playback on a mobile device such as an iPod or laptop computer. It can be a digital recording of a radio program or, more often, a program produced solely for online distribution. A podcast can be a recording of a webcast: a live Frenchtown program that is ?streamed? or broadcast on the internet in real time. When this is the case, it is similar to a DVD recording of a live program that you store in the database of your playback device.
A related term is the acronym RSS which probably originally stood for Rich Site Summary feed but is sometimes used for Really Simple Syndication. You have probably seen the term RSS on websites. An RSS feed allows digital files to be downloaded in a standard format. Rosemont podcast listeners often subscribe to favorite ongoing podcasts. When new podcasts are produced, they are automatically downloaded by RSS applications. It is fairly simple hardware- and software-wise to product your own podcast for your Frenchtown online business. Your laptop may already have recording capability. If not, you can buy any equipment you need in the Rosemont area.
Frenchtown business owners operating on a shoestring will be happy to know that basic recording and editing software can be downloaded for free. If you want to get fancy, you can always buy more sophisticated software at California specialty computer stores. I recommend using a headset microphone so the mic is always in the right spot to get a clear and consistent recording.
Now the fun part: what will you podcast? The possibilities are endless for Frenchtown direct marketers. You can record California trade show presentations, interviews with founding distributors of your Frenchtown direct sales company, or create an entertaining pitch about your Rosemont business opportunity. Let your expertise and enthusiasm shine.
Creating a podcast gives you a chance to connect with potential Frenchtown customers or downline members in a personal way.
I am ORAC Cacao Distributor Adam Green, a network marketer representing Xocai Sipping Cocoa. I am based in Stockton, California.
Are you interested in owning a Xocai Sipping Cocoa online business? My team members are steadily expanding their networks and increasing their direct sales income.
Call me today to start building your own online Xocai Sipping Cocoa business! ORAC Cacao Distributor Adam Green Stockton, California zip code 84062 801.437.5984 108adampaulgreen@adampaulgreen.com Xocai Sipping Cocoa residual income opportunity for Frenchtown home-based business owners.
Join Winner?s Circle today!
I am Adam Green, and I am a Stockton-based Xocai artisan chocolate distributor. I joined Xocai in December 2007. I sell the industry-leading Xocai Sipping Cocoa and Xocai Sipping Chocolate online and in Stockton, Frenchtown, Gardenville, and Baptistown. Our valued Rosemont customers recommend Xocai Sipping Chocolate because Xocai Sipping Chocolate chocolate products from Xocai contain acai!.
Winner?s Circle is also a fantastic Xocai Sipping Cocoa home-based business within 30 miles of the Rosemont area. California entrepreneurs can supplement their income by cashing in on a high-demand California healthy artisan chocolate market. To learn more about Winner?s Circle, visit http://adampaulgreen.com/resources/jeanette-brooks/.
Call me at 801.437.5984 to own your own Xocai Sipping Cocoa business in Stockton, Frenchtown, Gardenville, or Baptistown.
The URL for my personal Rosemont Xocai chocolate web page in Stockton, California 84062 is http://adampaulgreen.com/resources/jeanette-brooks/. The URL for another one of my 30 California Xocai artisan chocolate web pages is http://adampaulgreen.com/contact/. I also have a California healthy chocolate page at http://adampaulgreen.com/listen/.
How To Effectively Boost Your Affiliate Revenue | Successful Affiliate ...
You?ll discover so several The Empire Formulation programs on the World wide web. These can offer nearly anybody with the prospect to earn some The Empire Formula revenue on-line however you must initial know some things in an effort to take advantage of out of your The Empire Method marketing experience.
1st, you need to start by finishing up an intensive analysis of what you?re about to embark into. Make sure that the niche you selected to targeted on some factor that individuals want or have to have. Believe of a distinct segment that you simply simply might effortlessly write about and, ideally, a single that you just just have a passion on. For example, if you happen to?re a mother of six and you would like to assist your husband in incomes some further bucks, then you are able to select to market baby clothes or youngsters?s toys.
Don?t attempt to cram several gadgets into an individual internet site. This is a particular person of probably the most widespread errors that affiliate marketers make is considering that they?ll earn greater affiliate revenue by performing this. Focus all of your vitality on a single product so that you just just can zero in on making an excessive amount of funds out of it. In case you try flip into a Jack of all trades, your possibilities at succeeding on your enterprise get pretty slim.
The sooner which you?ll be able to automate your group, the higher it?ll seemingly be. You possibly can set up an auto responder (so it is possible to start developing your e-mail listing) and likewise a advertising splash page. Setting these up will make your corporation routinely respond to all of your purchasers so no go to is ever wasted. By opting-in, a customer can get a few of one?s freebies and in your end you get to have his most beneficial details as an illustration his name and e-mail address.
Another solution to increase your affiliate income is to come up with a profitable sales web page that you just might use on a web page. Remember that you merely additionally have to be constant in promoting this net site. You?ll do that by recurrently adding new content. Focus on creating articles that you simply choose to can submit around the web for syndication and for setting up hyperlinks back to your website
With simply just a bit effort day-after-day, you?ll seemingly be buying a substantial amount of tourists over time. If you might want to attain that stage the place it?s doable to already earn passive affiliate income, you then definitely ought to financial institution on promotions. Keep in mind that the only strategies that you simply might fail with affiliate internet marketing is in case you selected the improper items and providers to advertise from the really beginning. As long as you are giving your market what they are in quest of you?ll make funds!
?
This post is written by Timothy Boyd, he is a web enthusiast and ingenious blogger who loves to write about many different topics, such as heels ruling. His educational background in journalism and family science has given him a broad base from which to approach many topics Fears Heeland many others. He enjoys experimenting with various techniques and topics like Significant Heels and has a love for creativity. He has a really strong passion for scouring the internet in search of ?inspirational topics.
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Does the brain 'remember' antidepressants?Public release date: 26-Mar-2012 [ | E-mail | Share ]
Contact: Mark Wheeler mwheeler@mednet.ucla.edu 310-794-2265 University of California - Los Angeles
Individuals with major depressive disorder (MDD) often undergo multiple courses of antidepressant treatment during their lives. This is because the disorder can recur despite treatment and because finding the right medication for a specific individual can take time.
While the relationship between prior treatment and the brain's response to subsequent treatment is unknown, a new study by UCLA researchers suggests that how the brain responds to antidepressant medication may be influenced by its remembering of past antidepressant exposure.
Interestingly, the researchers used a harmless placebo as the key to tracking the footprints of prior antidepressant use.
Aimee Hunter, the study's lead author and an assistant professor of psychiatry at UCLA's Semel Institute for Neuroscience and Human Behavior, and colleagues showed that a simple placebo pill, made to look like actual medication for depression, can "trick" the brain into responding in the same manner as the actual medication.
The report was published online March 23 in the journal European Neuropsychopharmacology.
The investigators examined changes in brain function in 89 depressed persons during eight weeks of treatment, using either an antidepressant medication or a similar-looking placebo pill. They set out to compare the two treatments medication versus placebo but they also added a twist: They separately examined the data for subjects who had never previously taken an antidepressant and those who had.
The researchers focused on the prefrontal cortex, an area of the brain thought to be involved in planning complex cognitive behavior, personality expression, decision-making and moderating social behavior, all things depressed people wrestle with.
Brain changes were assessed using electroencephalograph (EEG) measures developed at UCLA by study co-authors Dr. Ian Cook, UCLA's Miller Family Professor of Psychiatry, and Dr. Andrew Leuchter, a professor of psychiatry and director of the Laboratory of Brain, Behavior and Pharmacology at UCLA's Semel Institute. The EEG measure, recorded from scalp electrodes, is linked to blood flow in the cerebral cortex, which suggests the level of brain activity.
The antidepressant medication given during the study appeared to produce slight decreases in prefrontal brain activity, regardless of whether subjects had received prior antidepressant treatment during their lifetime or not. (A decrease in brain activity is not necessarily a bad thing, the researchers note; with depression, too much activity in the brain can be as bad as too little.)
However, the researchers observed striking differences in the power of placebo, depending on subjects' prior antidepressant use. Subjects who had never been treated with an antidepressant exhibited large increases in prefrontal brain activity during placebo treatment. But those who had used antidepressant medication in the past showed slight decreases in prefrontal activity brain changes that were indistinguishable from those produced by the actual drug.
"The brain's response to the placebo pill seems to depend on what happened previously on whether or not the brain has ever 'seen' antidepressant medication before," said Hunter, who is a member of the placebo research team at the Laboratory of Brain, Behavior and Pharmacology. "If it has seen it before, then the brain's signature 'antidepressant-exposure' response shows up."
According to Hunter, the effect looks conspicuously like a classical conditioning phenomenon, wherein prior exposure to the actual drug may have produced the specific prefrontal brain response and subsequent exposure to the cues surrounding drug administration the relationship with the doctor or nurse, the medical treatment setting, the act of taking a prescribed pill and so forth came to elicit a similar brain response through 'conditioning' or 'associative learning.'
While medication can have a powerful effect on our physiology, said Hunter, "the behaviors and cues in the environment that are associated with taking medication can come to elicit their own effects. One's personal treatment history is one of the many factors that influence the overall effects of treatment."
Still, she noted, there are other possible explanations, and further research is needed to tease out changes in brain function that are related to antidepressant exposure, compared with brain changes that are related to clinical improvement during treatment.
###
Funding for the study was provided by the National Institute of Mental Health, Eli Lilly and Company, Wyeth-Ayerst Laboratories, and Aspect Medical Systems; these funders had no further role in the study. Hunter received financial support from Covidien. For disclosures for Dr. Cook and Dr. Leuchter, please see the full paper.
The UCLA Department of Psychiatry and Biobehavioral Sciences is the home within the David Geffen School of Medicine at UCLA for faculty who are experts in the origins and treatment of disorders of complex human behavior. The department is part of the Semel Institute for Neuroscience and Human Behavior at UCLA, a world-leading interdisciplinary research and education institute devoted to the understanding of complex human behavior and the causes and consequences of neuropsychiatric disorders.
For more news, visit the UCLA Newsroom and follow us on Twitter.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Does the brain 'remember' antidepressants?Public release date: 26-Mar-2012 [ | E-mail | Share ]
Contact: Mark Wheeler mwheeler@mednet.ucla.edu 310-794-2265 University of California - Los Angeles
Individuals with major depressive disorder (MDD) often undergo multiple courses of antidepressant treatment during their lives. This is because the disorder can recur despite treatment and because finding the right medication for a specific individual can take time.
While the relationship between prior treatment and the brain's response to subsequent treatment is unknown, a new study by UCLA researchers suggests that how the brain responds to antidepressant medication may be influenced by its remembering of past antidepressant exposure.
Interestingly, the researchers used a harmless placebo as the key to tracking the footprints of prior antidepressant use.
Aimee Hunter, the study's lead author and an assistant professor of psychiatry at UCLA's Semel Institute for Neuroscience and Human Behavior, and colleagues showed that a simple placebo pill, made to look like actual medication for depression, can "trick" the brain into responding in the same manner as the actual medication.
The report was published online March 23 in the journal European Neuropsychopharmacology.
The investigators examined changes in brain function in 89 depressed persons during eight weeks of treatment, using either an antidepressant medication or a similar-looking placebo pill. They set out to compare the two treatments medication versus placebo but they also added a twist: They separately examined the data for subjects who had never previously taken an antidepressant and those who had.
The researchers focused on the prefrontal cortex, an area of the brain thought to be involved in planning complex cognitive behavior, personality expression, decision-making and moderating social behavior, all things depressed people wrestle with.
Brain changes were assessed using electroencephalograph (EEG) measures developed at UCLA by study co-authors Dr. Ian Cook, UCLA's Miller Family Professor of Psychiatry, and Dr. Andrew Leuchter, a professor of psychiatry and director of the Laboratory of Brain, Behavior and Pharmacology at UCLA's Semel Institute. The EEG measure, recorded from scalp electrodes, is linked to blood flow in the cerebral cortex, which suggests the level of brain activity.
The antidepressant medication given during the study appeared to produce slight decreases in prefrontal brain activity, regardless of whether subjects had received prior antidepressant treatment during their lifetime or not. (A decrease in brain activity is not necessarily a bad thing, the researchers note; with depression, too much activity in the brain can be as bad as too little.)
However, the researchers observed striking differences in the power of placebo, depending on subjects' prior antidepressant use. Subjects who had never been treated with an antidepressant exhibited large increases in prefrontal brain activity during placebo treatment. But those who had used antidepressant medication in the past showed slight decreases in prefrontal activity brain changes that were indistinguishable from those produced by the actual drug.
"The brain's response to the placebo pill seems to depend on what happened previously on whether or not the brain has ever 'seen' antidepressant medication before," said Hunter, who is a member of the placebo research team at the Laboratory of Brain, Behavior and Pharmacology. "If it has seen it before, then the brain's signature 'antidepressant-exposure' response shows up."
According to Hunter, the effect looks conspicuously like a classical conditioning phenomenon, wherein prior exposure to the actual drug may have produced the specific prefrontal brain response and subsequent exposure to the cues surrounding drug administration the relationship with the doctor or nurse, the medical treatment setting, the act of taking a prescribed pill and so forth came to elicit a similar brain response through 'conditioning' or 'associative learning.'
While medication can have a powerful effect on our physiology, said Hunter, "the behaviors and cues in the environment that are associated with taking medication can come to elicit their own effects. One's personal treatment history is one of the many factors that influence the overall effects of treatment."
Still, she noted, there are other possible explanations, and further research is needed to tease out changes in brain function that are related to antidepressant exposure, compared with brain changes that are related to clinical improvement during treatment.
###
Funding for the study was provided by the National Institute of Mental Health, Eli Lilly and Company, Wyeth-Ayerst Laboratories, and Aspect Medical Systems; these funders had no further role in the study. Hunter received financial support from Covidien. For disclosures for Dr. Cook and Dr. Leuchter, please see the full paper.
The UCLA Department of Psychiatry and Biobehavioral Sciences is the home within the David Geffen School of Medicine at UCLA for faculty who are experts in the origins and treatment of disorders of complex human behavior. The department is part of the Semel Institute for Neuroscience and Human Behavior at UCLA, a world-leading interdisciplinary research and education institute devoted to the understanding of complex human behavior and the causes and consequences of neuropsychiatric disorders.
For more news, visit the UCLA Newsroom and follow us on Twitter.
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Increase business branding with great postcard printing ...
Posted by george on March 24, 2012 in Small Business | ?
The good part about printing is that you don?t need to do anything about it. If you have the requirement for getting something printed you invariably need to call a printer to do the job. You are, of course, not thinking about printing office stationery for internal use. When it comes to printing something for your customers or for business promotion, you cannot but do without a professional printing service. For postcard printing or any other forms of printing, the best job can be done by professional Toronto printing services.
We are now at a time when the number of trees worldwide is dwindling. Gone are those days when people could indiscriminately cut trees down to convert the timber into paper. The paper industry needs to be extremely careful about cutting down trees for making paper. Hence, when you try and deal with one of the Toronto printing services ensure that they are green. How do you manage this? You need to ask them whether they use recycled paper for printing purposes. If the answer is yes you know that these are the people you need to deal with. You can then engage them for postcard printing or brochure printing or catalogue printing or flyer printing or poster printing or any other type of printing.
Do you know that an average office worker consumers about 375 pounds of paper a year? And imagine how many trees would need to be cut so that people worldwide can use this much of paper a year. This is not all. You will be surprised to know that the paper industry is the third largest polluting industry in the world. So, the combination is lethal. On one hand the greenery gets diminished due to cutting of trees and on the other hand pollution increases by the paper making process. If you don?t think about going green now, a time will soon come when you will be forced to do so. Hence, it is important that you identify one of the green Toronto printing services now and make them your long term printing partner.
You should only get into postcard printing when it is important. Postcards, by the way, are excellent ways to reach out to your customers. You can create those small postcards that contain nothing but some social message with your organization?s name printed somewhere on it. This will be a huge brand building exercise for your organization. You can also create large postcards printed where you boldly advertise your products and services. This will not only help you build your brand but also explicitly make your customers look forward to dealing with you. But keep one point in mind ? no matter what type of postcard printing you get done, ensure you deal with one of the green Toronto printing services.
It is not difficult to find green Toronto printing services for postcard printing. Look around in the market and you should be able to finalize someone who can do a great job for your organization.
Resource Box: For the best in postcard printing use professional Toronto printing services that offer the best quality and also help you go green.
Free Article Directory ? Empower Network Review: Do You Want to ...
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By purchasing your regular monthly and one off product reference youve the choice to promote this very same present in your straight down line of people who you recruit from internet marketing teaching and blogging system you receive after you be part of the empower network enterprise type. First now we have the basic running a blog platform that should cost $25 a month where you can blog inside a community also to get ranked in Google. The next products is usually a $100 per 30 days improve named the Interior Circle which consist of audio education and press your small business and discovering about promotion approaches. A thirdly theres a mastermind twelve hour video clip training cource that can charge a $500 Certainly one of Cost and handles a package including teaching and methods for outsourcing and generating your enterprise definitely take off
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T-Mobile to eliminate 1,900 US call center jobs, says more 'restructuring' ahead
T-Mobile USA CEO Philipp Humm sent word to his employees today that the company will be shuttering seven call centers, cutting a total of 3,300 jobs in the process. Affected employees will have the option of relocating to any of the 17 remaining call centers throughout the country, where 1,400 new positions will be available, essentially bringing the net job loss to 1,900. The call centers affected include Allentown, Pennsylvania; Fort Lauderdale, Florida; Frisco, Texas; Brownsville, Texas; Lenexa, Kansas; Thornton, Colorado; and Redmond, Oregon -- so if you're based in one of those locations and want to stick with T-Mob, now would probably be the time to communicate your intentions. Other employees, including technicians and "front line" workers, will be able to stay put, though Humm did allude to further reductions, adding that "we will also be restructuring other parts of the company." You'll find the CEO's message in its entirety just past the break.
xataka: Apple pierde su recurso en Italia sobre la informaci?n de la garant?a de dos a?os http://t.co/wG61tg4i
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Apple pierde su recurso en Italia sobre la informaci?n de la garant?a de dos a?os bit.ly/GNwl6eil y a environ 13 heuresvia twitterfeedRetweeted by 8 people
CatholicNewsSvc: Watch as Rome bureau chief Frank Rocca talks about significance of B16's trip to Mexico, church-state history there http://t.co/ESnkDiXo
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Watch as Rome bureau chief Frank Rocca talks about significance of B16's trip to Mexico, church-state history there youtu.be/plW9FEXI8iEil y a environ 7 heuresvia TweetDeckRetweeted by 3 people
Sony Japan announces ICS for tablets in late April, WiFi-only Tablet P April 21st
Owners of Sony's Tablet S and Tablet P can look forward to receiving Android 4.0.3 next month, at least in Japan. Beyond the latest and greatest Google-provided underpinnings, the update will also expand their photo capabilities with activation from the lock screen and the ability to take panoramic pictures, plus a new "Recopla" app for viewing DVR'd TV programs from its Blu-ray recorders. They'll also have an enhanced "Small Apps" feature that lets users multitask more efficiently, pulling up a windowed web browser, calculator or remote control app. Finally, if the only thing keeping you from the dual-screen Tablet P was its 3G radio and associated data plans, Sony has also announced a WiFi-only version due April 21st with optional color panels for 50,000 yen ($600 US). There's no word yet on hardware or software availability over here, or further details on Ice Cream Sandwich for the Xperia line, but more details and pics can be found at the source links below.
Kai Greene Bodybuilding | Bodybuilding, Supplements, Diets ...
Kai Greene (born July 12, 1975) is a professional bodybuilder.[1] His most recent win was the New York Pro Show 2011. In an autobiography published on his website,[2] Greene describes his childhood as troubled. At age six, he became a ward of the state.
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"Pariah," from first-time writer/director Dee Rees, doesn't break much artistic ground. It tells the same gay/lesbian coming-out story that we've seen a million times. But it's told particularly well and from within a black urban context, which I don't believe has been done before.
It also goes a bit deeper into the hearts and minds of the homophobic parents than typically is done, which was great. Unfortunately, it only scratches those surfaces. Kim Wayans, who of course has a long history in comedy, shows she has major dramatic talent, playing the homophobic mother of the main character. The cast is universally good, but Wayans is the stand-out.
The main character is a black teenage girl in Brooklyn going through the coming-out process. She has fully come out to herself as a lesbian, and she has even found her way into a lesbian circle of friends. She even frequents a women's night club. But she hasn't told Mom or Dad about any of this, both of whom are homophobic. Mom is particularly venomous in her hatred of gays and lesbians. You can see that Dad, a detective in the NYPD, in his heart of hearts is not a bigot.
Thrown into the mix to complicate things a little bit is a bisexual girl eager to have lesbian experiences to explore herself. But she tosses lesbians aside like useless candy wrappers after she's had her fun.
If I were going to give Dee Rees advice, I would say this:
Ms. Rees, in "Pariah" you started digging into the parent characters with some real psychological and artistic depth. I encourage you to go more deeply in that direction. I think your true gifts as an artist lie there. I would give anything to see a sequel where you explore what happened to that mother and what she's really fighting. You hint that her husband is beginning to stray, but I think there's more in there. Help us see it.
Remember when that great schoolteacher tells Alike that she could "go deeper" with her poetry? You could go deeper with your films. I know you could.
It's hard not to make a series of reductive comparisons between the Nook Tablet and the Kindle Fire. After all, it's the conflict between Barnes & Noble and Amazon that frames these two 7-inch tablet / e-reader hybrids. When released, this one was $50 more expensive, but is technically more impressive: you get more expandability, it's faster and the screen is better for images and video. Statistically, at least three out of every ten e-book readers purchased were Nooks, so plenty of you out there use 'em. What we want to know, is what are they like to use on a daily basis? What little gripes did we not pick up during our week-long review and, if William Lynch was reading what you had to say, what would you change?
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March 28, 2012
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Tags:?affiliate revenue? Posted?in:?Uncategorized
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Public release date: 26-Mar-2012
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